21-P035 Drosophila neurotrophic factor DmMANF
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منابع مشابه
21-P035 Drosophila neurotrophic factor DmMANF
delayed chondrocyte differentiation since Indian hedgehog (Ihh) is not expressed in the ulna of Ulnaless or Hoxa11//d11/ mice. Fibroblast growth factor 3 (Fgfr3), which is expressed at low levels in distal cells and at high levels in columnar chondrocytes, shows low expression in the Ulnaless and Hoxa11//d11/ zeugopod resembling the expression level in distal chondrocytes. However, the Unique c...
متن کاملEvidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.
In vertebrates the development and function of the nervous system is regulated by neurotrophic factors (NTFs). Despite extensive searches no neurotrophic factors have been found in invertebrates. However, cell ablation studies in Drosophila suggest trophic interaction between neurons and glia. Here we report the invertebrate neurotrophic factor in Drosophila, DmMANF, homologous to mammalian MAN...
متن کاملDownregulation of DmMANF in Glial Cells Results in Neurodegeneration and Affects Sleep and Lifespan in Drosophila melanogaster
In Drosophila melanogaster, mesencephalic astrocyte-derived neurotrophic factor (DmMANF) is an evolutionarily conserved ortholog of mammalian MANF and cerebral dopamine neurotrophic factor (CDNF), which have been shown to promote the survival of dopaminergic neurons in the brain. We observed especially high levels of DmMANF in the visual system of Drosophila, particularly in the first optic neu...
متن کاملBrain-derived neurotrophic factor:
Dekan Summary BDNF (brain-derived neurotrophic factor) plays an important role in neuronal survival, growth and maintenance of several neuronal systems, serves as neurotransmitter modulator and participates in plasticity important for learning and memory. BDNF is widely expressed in the CNS, beginning early in development and extending throughout life. In the mammalian brain, it is most abundan...
متن کاملBrain-Derived Neurotrophic Factor, Ciliary Neurotrophic Factor, and Basic Fibroblast Growth Factor
Methods. Retinal ischemia was induced in Lewis albino rats by increasing intraocular pressure to 160 mm Hg for 90 minutes. The agents or buffer controls were injected intravitreally at different times, either before or after the ischemic insult, and the postischemic survival time was either 7 or 14 days. The degree of retinal damage was assessed from plastic-embedded sections by cytologic analy...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.900